— Diet Wiki Selected excerpts from the best websites —
Orlistat is an anti-obesity drug manufactured in Switzerland by La Roche Ltd. The US Food and Drug Administration approved the low dosage Orlistat and allow it to be sold over the country in 2007.
Orlistat is used together with a reduced-calorie diet to help you lose weight and to help keep the lost weight from returning. It is also used in overweight people who may also have diabetes, high blood pressure, high cholesterol, or heart disease.
Orlistat works by keeping your intestines from absorbing some of the fats from the food that you eat. The undigested fat goes out of your body in your bowel movements.
This medicine is available both over-the-counter (OTC) and with your doctor’s prescription.
Dietary fats need to be broken down into smaller pieces before the body can absorb them. Orlistat works by blocking the enzyme that breaks down fats in your diet. This undigested fat then passes out of your body in your bowel movement. Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories.
Studies have shown that, on average, orlistat, plus a weight-reducing diet and exercise, causes more weight loss than a weight-reducing diet and exercise alone. Some people lose 10% or more of their body weight within six months with the help of orlistat. In others, it is less effective.
One reason why orlistat may not work is that you may think that you can relax your weight-reducing diet, and the orlistat will ‘do it all’. This is not true. In order to lose weight you still have to eat less and exercise regularly. Remember, orlistat prevents only some of the fat that you eat from being absorbed (just under a third). But, if you do not keep to a healthy weight-reducing diet, and you eat more fat (chocolates, cakes, etc), the extra fat that you eat will easily cancel out the effect of the orlistat.
For Orlistat to work, it must be used in conjunction with other weight loss tactics. These include a regular exercise programme and a healthy diet plan. When taken on its own, Orlistat may not reduce weight, as it doesn’t burn existing fat.
If used together with additional weight loss tactics, Orlistat has been shown to be effective at aiding weight loss.
One study found that people who took Orlistat and kept to a low-calorie diet lost on average 1.25 stone (8.1kg) a year, which was 6lb (2.8kg) more than those who did not take Orlistat during the same time period.
Another study found that 743 obese patients taking Orlistat for weight loss had lost on average 10.3kg of weight after one year. This is in contrast to the 6.1kg patients not taking Orlistat lost.
Other studies have also found that people following this course of treatment could lose up to 10% of their body weight in a year.
Orlistat does not act systemically; instead, it exerts its therapeutic activity in the lumen of the stomach and small intestine by inhibiting gastric and pancreatic lipases that hydrolyze triglycerides into free fatty acids and monoglycerides. This restricts the intestine’s ability to absorb triglycerides, which are excreted fecally instead, thus inhibiting absorption of dietary fats by approximately 30%.15 In a 16-week randomized, controlled study, orlistat 60 mg resulted in significant weight loss compared with placebo (3.05 kg vs. 1.9 kg; P <.001) in mildly to moderately overweight adults.16 Another study evaluated the ability of orlistat 60 mg to produce a change in visceral adipose tissue in overweight patients.17 After 24 weeks, orlistat demonstrated a significant decrease in visceral adipose tissue versus placebo (–15.7% vs. –9.4%; P <.05). In addition, there was a trend toward a greater reduction in liver fat (which is independently linked to dyslipidemia and insulin resistance) and intermuscular adipose tissue (which is associated with metabolic abnormalities related to muscle and glucose metabolism).17 These findings suggest that orlistat 60 mg, along with a reduced-calorie, low-fat diet, may be an effective weight-loss tool for reducing metabolic risk factors associated with upper-body adiposity.
From 1 in 250 and 1 in 70 patients experienced one or more of these symptoms in the first year. Generally, the side effects occurred within three months of starting therapy. In about 50% of patients, the side effects resolved within one to four weeks, but the effects in some patients lasted six months or longer. To reduce the occurrence of these side effects, meals should contain no more than 30% fat because it is the unabsorbed fat that causes most of the symptoms. alli causes fewer side effects because it contains half the dose of prescription-strength orlistat. Patients receiving orlistat with a history of oxalate kidney stones may develop increased levels of oxalate in their urine, which may increase the risk of kidney stones.
Liver failure has been reported in patients treated with orlistat. Orlistat should be discontinued if symptoms of liver failure (loss of appetite, anorexia, itching, jaundice, dark urine, light colored stools, or right upper abdominal pain) occur while taking orlistat.
120 mg orally three times a day with each main meal containing fat. The dose may be taken during the meal or within 1 hour of completing the meal.